Cause
Protein in urine are closely related to the barrier of renal glomeruli.
Proteinuria and Kidney Disease
There are three layers in renal glomerular capillaries, which are called endothelial cells, basilar membrane, and epithelial cells in order. In all of the three layers, there are filtration pores with different sizes and negative charges. In addition, in every layer of filtration, there are many substances which carry negative charges. So the permeability of filtration membrane demands that they must carry negative charges. These materials reject the plasma protein, which carries negative, and limit their filtration. Although the effective diameter of plasma protein is 3.5nm, it can not pass through the filtration membrane for it carries negative charges.
Suggestion for ESRD Patients to Improve Kidney Function
When kinds of pathological damage takes places in kidney, including primary one and secondary one, the damage will lead to the block of micro-circulation in partial area, which causes the insufficiency of blood and oxygen in the renal tissues. Because of insufficiency of blood and oxygen, the renal capillary endothelial cells will be damaged. Once it is damaged, it will attract the infiltration of inflammatory cells, and relieves pathological inflammatory mediators such as IL-1、TNF—α and so on. All these pathological damage can lead to the inflammatory response which can lead to the renal damage.
When kidney is in pathological condition, there will be a series of change in the renal glomeruli, which can make the filtration pore become larger or narrower. GBM is broken. The charge barrier is damaged. The permeability increases. The glycoprotein decreases or increases, both of which can lead to the filtration amount of plasma protein increases obviously, thus causing protein in urine in clinic.
From the above mentioned, we can get a conclusion why there is renal protein in urine. After knowing it, we will recommend a therapy which is called Micro-Chinese Medicine Osmotherapy. It contains many nutritious and active materials, which can repair the damaged filtration membrane and so on after entering the body. In addition, it can also improve the insufficiency of blood and oxygen in the kidney, which can rebuild the renal structure and revive renal function.
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