Helpful Treatments for IgA Nephritis

So far, there isn’t any satisfactory treatment with western medicine toward this disease. Adrenal cortical hormone with or without immunosuppressants has different effects in treating patients associated with progressive decrease in renal function. Recent data indicates that using adrenal cortical hormone every two days can help reduce proteinuria in patients that over 1g/d, while relax it for those with minimal change nephropathy caused by IgA deposition. Taking such medicine together with cyclophosphamide, Panshengding and Huafulin can reduce proteinuria without affecting filtration rate of glomerulus; and together with Cyclosporin A also can reduce proteinuria, yet decreasecreatinine clearance rate. Effects for medicines, such as Phenytoin Sodium, Antiplatelet drugs, Disodium Cromoglycate, Diphenyl-Hydantoin, etc., are not confirmed. Although it is reported that Urokinase can protect the GFR, however, it has not been demonstrated yet.
Excision of tonsil may be good for patients suffering recurrent tonsillitis; Preventing and curing infection with antibiotics may be helpful to those having acute nephritis syndrome and acute renal failure. A smaller series of observation represents that using fish-oil preparations can reduce proteinuria and increase filtration rate of glomerular. For patients suffering from severe chronic IgA nephropathy (filtration rate of glomerulus decreasing 2-4ml/min per month), using large dose of immunoglobulin by intravenous perfusion can stop glomerular filtration rate from decreasing, improve blood urine and proteinuria - Natural Cure for Proteinuria As Kidney Disease Symptom, yet will always be back after stop the medicine. For those who have high blood pressure and severe proteinuria, ACEI can slow down the drop of glomerular filtration rate, and decrease the proteinuria. Therefore, it is the first choice to lower blood pressure in treating severe chronic IgA nephropathy - Iga Nephropathy Treatment. However, it is not clear whether ACEI is efficient to patients with normal blood pressure.

After patients at late and end stage receive kidney transplantation, IgA deposits in mesangial area in the transplanted kidneys. IgA sediments in mesangial area of the provided kidney always disappear quickly if the kidneys of patients with subclinical chronic IgA nephropathy are transplanted into those who have non-chronic IgA nephropathy uremia. Transplanted kidney associated with recurrent chronic IgA nephropathy does not certainly develop into progressive renal failure. Nevertheless, the immunosuppressive therapies carried out after kidney transplantation, including which followed the transplantion, including Cyclosporin A, can not keep them from developing. For transplanted kidneys from corpse, survival rates for patients with one-year and three-year transplanted kidney are respectively 87% and 77%. Yet for some exceptions that have IgA antibodies against HLA antigen, that for those with the two-year is 100%. It is reasonably to believe that the above-mentioned antibodies greatly contribute to the survival.