2015年2月8日星期日

The Brief Introduction of IgA Nephropathy

The body produces IgA antibody that belongs to antimicrobial antigen, a large amount of IgA and IgA immune complex deposition in mesangial region, activating the way beside alexin and leading to the damage of kidney. This is the so-called IgA Nephropathy.
IgA Nephropathy is a special kind of Glomerular Nephritis which happens more commonly in children and young people. It always with infection of the upper respiratory tract before IgA Nephropathy. The characteristic of lesion is the increasing of mesangium and we can use immuno fluorescence method to inspect IgA deposition in mesangial region.
IgA Nephropathy is a kind of Chronic Glomerular Disease which causes by many pathogenies that has the same feature of immunopathology. There are about 40%~45% of patients clinically appear gross hematuria or microscopic hematuria, and 35%~40% of patients appear microscopic hematuria(Hematuria and Kidney Disease) with proteinuria(Proteinuria and Kidney Disease), others emerge nephrotic syndrome and renal failure.
IgA Nephropathy is a common Glomerular Disease, which is epidemic in different continents and countries, or has a great difference in different regions of the country. For example, in Japan and Singapore, the morbidity of IgA Nephropathy account for 50% of Primary Glomerular Disease, while it is only 2% in Indian of west America.
In general, the morbidity in Caucasian and Asian is obvious higher than that in Negroid. In our country, the morbidity of IgA Nephropathy account for 26%~34% of Primary Glomerular Disease. There are 2 men for every 1 women. Hematuria-dominated IgA Nephropathy has no specific treatments at present. There is a great difference in pathology types and glomerular damage, so we should closely observe the frequency of gross hematuria, the extent of the proteinuria, the situation of hypertension and the damage of renal function, adopting relevant precaution.

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