Renal stone Immunotherapy from the deposition of mineral substances in renal pelvis and calices, and in some occasions, calculus can also occur to renal calices. High calcium excretion is the main reason of mineral substances deposition. For example, excessive perspiration lessens urine excretion, and long term exposition to sunshine and especially to ultraviolet irradiation enhances the synthesis of vitamin D and vitamin A, which promotes the calcium absorption ability of small intestines. Thus calcium concentration in urine increases, and so does the incidence of calcium deposition, which finally leads to the formation of calculus.
Calcium oxalate calculus is the most common calculus and it generally accounts for 80% of all renal calculus. This problem commonly occurs in young adults and especially in men. Calcium oxalate calculus forms in acidic or neutral urine and in X-line imaging one can clearly observe the existence of renal calculus. Excessive intake of foods rich in oxalate and the deficiency in vitamin B1 and vitamin B6 will contribute to the increase of oxalate in body. In some cases, the water in one certain area contains relatively high quantity of oxalate, so the local people become more vulnerable to this due problem.
The incidences of other calculus are relatively smaller. And this article mainly explains the formatting mechanism and the corresponding preventing mechanism of calcium oxalate calculus.
Generally, the combination of oxalate with calcium deposits in urine and the untimely or incompletely excretion of these depositions leads to the formation of renal calculus. And several specific factor mainly contributes to this process.
Excessive intake of foods high in oxalate leads to overload working of kidneys in excreting oxalate. Some foods are high in purine, and the metabolic production of purine is urea which enhances the deposition of oxalate in urine. Another reason is excessive intake of protein. Protein contains materials like glycine, and protein can also enhance the calcium absorption ability of intestinal tract. In addition, intake of foods high in lipid and sugar can also increase the occurrence of calculus.
Then how to effectively prevent the formatting of calculus?
Firstly we need to avoid of excessive intake of foods high in oxalate and protein as well as calcium. And secondly, we can also start from preventing the combination of oxalate and calcium. For the second method, we can achieve this purpose by increasing intake of citric acid which is much more powerful in combining with calcium then that of oxalate, thus there will be less deposition of calcium oxalate salt in urine. In addition, vitamin B6 enhances the combination of critic acid with calcium. And patients should also increase the water drink volume to dilute urine, as well as increasing urine excretion. by this, the deposition of material substances will be effectively prevented.
