Pathology: various pathologic styles can cause Chronic Nephritis, such as mesangial proliferative glomerulonephritis(IgA and non IgA mesangial proliferative Nephritis), mesangial capillary nephritis, membranous nephropathy, local segmental glomerulonephritis and so on. In the late stage, all these kinds of pathologic styles transform into different severity of glomerulosclerosis, as well as renal tubule atrophy and interstitial fibrosis. In the end stage, kidneys shrink and renal cortex becomes thin. As a result, these pathologic diseases worsen into sclerosing glomerulonephritis.
Clinical manifestations: Chronic Nephritis can occur among any age group, especially young and middle age. This disease often attacks males. And it develops slowly and is underlying. Clinical manifestations are various with emphasis of Proteinuria(Proteinuria and Kidney Disease), hematuria(Hematuria and Kidney Disease), hypertension(High Blood Pressure and Kidney Disease), and edema(Swelling and Kidney Disease). in addition to different severity of renal failure and changeable disease condition, chronic nephritis worsens into chronic renal failure processively.
Treatment: the main purpose of the treatment of chronic nephritis is to prevent and delay processive worsening of renal functions, and to better or relieve clinical manifestations and complications rather than eliminating red cells or trace of albumin in urine. Therefore, these following measures can be taken:
1. Control hypertension actively.
Hypertension can promote glomerulosclerosis and worsen renal functions. So controlling hepertension is a vital step.
According to recent studies, ACEI can lower blood pressure and decrease urine protein, as well as delaying the worsening of renal functions. So ACEI is the first drug of controlling hypertension for Chronic Nephritis. But those patients with renal failure should avoid heperkalemia and some patients who haven’t taken dialysis but with serumcreatinine over 350umol/L are suggested not to take ACEI.
Few patients taking ACEI may suffer from continuous dry cough.
2. Limit protein and phosphorus intake.
Patients with Azotemia should limit protein and phosphorus intake.
3. Take antiplatelet medicines
Large dose of dipyridamole(300-400/d), small doze of aspirin(40-300mg/d)can perform antiplatelet role. Besides that, present study results have proven that these two medicines can degrade urine protein for those patients with mesangial capillary glomerulonephritis.
4. Avoid those factors which can aggravate kidney lesion.
Infection, fatigue, pregnancy, and some renal toxic medicines like Aminoglycoside antibiotics, all can lead to kidney lesion and damage renal functions. So these factors should be avoided.
Chronic Nephritis is easy to worsen into renal failure, so paying more attention to precaution and treatment is vital. If you still have any other questions, you can consult our online experts or send e-mail to me.
