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Why Is Chronic Kidney Disease (CKD) Associated with Decreased GFR

GRF, Short for glomerular filtration rat, may be not so familiar to some people. GFR refers to the leachate volume filtered out by the two kidneys in unite time. Generally speaking, decreased GFR is the typical characteristic of Chronic Kidney Disease (CKD). Then why is Chronic Kidney Disease associated with decreased GFR?
It is known to all that our kidneys have filtration function, but you may not know it is the different functional cells play the filtration function. Normally, the filtration function is performed by glomerular mechanical barrier and charge barrier which is the joint action of the functional cells. Under the effect of these two barriers, toxic substances and other waste products in blood will be filtered out of our body and meanwhile, the nutrient substances are reabsorbed by renal tubules. This is the normal condition of kidneys.
When it comes to Chronic Kidney Disease, we usually take GFR as the standard of measuring renal function. With the invasion of disease, our body will produce antibody to against these virus and then as a result, immune complexes will be generated. Since blood component is changed, kidneys have to work more to excrete these wastes, which, exactly, beyond the service ability of our kidneys. With long-term overwork, functional cells will be damaged gradually. Consequently, GFR decreases. In this light, we can get the conclusion that decrease GFR appearing among people with Chronic Kidney Disease is actually caused by the damage of renal functional cells.

As GFR decreases, the leachate volume excreted by glomeruls decreases therewith, leading to the accumulation of these toxic substances in blood. We know toxic substances can cause damages to many of our organs, which will cause other diseases. That is to say, if we leave Chronic Kidney Disease uncontrolled, some complications will appear. Therefore, once we suffer from Chronic Kidney Disease, we should receive effective treatment as early as possible, so as to avoid damaging other organs. For more information, please email to me or consult our consultant online.

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