Chronic Kidney Disease (CKD). Then why is Chronic Kidney Disease associated with decreased GFR?
It is known to all that our kidneys have filtration function, but you may not
know it is the different functional cells play the filtration function.
Normally, the filtration function is performed by glomerular mechanical barrier
and charge barrier which is the joint action of the functional cells. Under the
effect of these two barriers, toxic substances and other waste products in blood
will be filtered out of our body and meanwhile, the nutrient substances are
reabsorbed by renal tubules. This is the normal condition of kidneys.
When it comes to Chronic Kidney Disease, we usually take GFR as the standard
of measuring renal function. With the invasion of disease, our body will produce
antibody to against these virus and then as a result, immune complexes will be
generated. Since blood component is changed, kidneys have to work more to
excrete these wastes, which, exactly, beyond the service ability of our kidneys.
With long-term overwork, functional cells will be damaged gradually.
Consequently, GFR decreases. In this light, we can get the conclusion that
decrease GFR appearing among people with Chronic Kidney Disease is actually
caused by the damage of renal functional cells.
As GFR decreases, the leachate volume excreted by glomeruls decreases
therewith, leading to the accumulation of these toxic substances in blood. We
know toxic substances can cause damages to many of our organs, which will cause
other diseases. That is to say, if we leave Chronic Kidney Disease uncontrolled,
some complications will appear. Therefore, once we suffer from Chronic Kidney
Disease, we should receive effective treatment as early as possible, so as to
avoid damaging other organs. For more information, please email to me or consult
our consultant online.