● Glomerular High Filtration Stage
In this stage, glomerular filtration rate achieves as high as one hundred and
twenty percent to one hundred and forty percent and people with Diabetic
Nephropathy have enlarged kidneys. Normally, as long as patient with stage one
Diabetic Nephropathy has better about their blood glucose, then the pathological
changes appearing in their kidneys is reversible.
● Normal Albuminuria Stage
In this stage, the glomerular filtration rate is still high and meanwhile,
intermittent microalbuminuria can be found. The excretion of protein in urine is
normal at rest, but higher after exercises.
● Early Stage of Diabetic Nephropathy
In this stage, glomerular filtration rate begins to decrease and it is normal
or somewhat lower than the normal value. Moreover, high blood pressure and
persistent microalbuminuria are the symptoms of Diabetic Nephropathy in this
stage. Furthermore, in this stage, excretion rate of protein increases, even if
patients do not do any exercise.
● Clinical Diabetic Nephropathy
Usually, patients with this stage Diabetic Nephropathy will have large amount
of proteinuria, swelling and high blood pressure in the following three or four
years. In this stage, glomerular filtration rate is significantly lower than
● End Stage of Renal Failure
Due to the thickness of glomerular basilar membrane, glomerular capillary
lumen has a progressive narrowing. More and more glomerular dies, renal function
will decreases, leading to the occurrence of renal failure. Usually, in this
stage, kidneys have lost almost all their functions and patients can not live a
What need to be paid attention about this kind of Chronic Kidney Disease is
that the natural progress of each stage of Diabetic Nephropathy is three to five
years. That is to say if patients with Diabetic Nephropathy leave their disease
uncontrolled, then their disease will develop into renal failure within at most
twenty years. Therefore, to stop the rapid development of Diabetic Nephropathy,
receiving treatment timely is very necessary.