Nephrotic Syndrome can be divided into five stages.
In the first stage, patients with Diabetic Nephropathy are in the high
filtration stage. This stage is characterized by increased GFR(glomerular
filtration rate), and increased kidney size. Diabetics who are diagnosed with
IDDM have had these changes. At the same time, blood flow in the kidney and
perfusion and inner pressure in the capillary blood cells are both high.
In the second stage, patients with Diabetic Nephropathy have normal albumin.
The blood pressure in the first and second stage is usually normal. Their
GFR(glomerular filtration rate)increases. UAE is normal.
In the third stage, patients with Diabetic Nephropathy have a little
increased blood pressure. Declining blood pressure can decrease the discharge of
trace albumin to a degree. It is obvious in this stage that GBM becomes thicker.
In addition, the matrix in mesangial area is also more obvious.
In the fourth stage, patients with Diabetic Nephropathy have large amount of
proteinuria, which is unselective proteinuria. Blood pressure increases, and the
GBM becomes thicker obviously. Matrix in mesangial area becomes wider as well.
In addition, deserted glomeruli increased.
In the fifth stage, patients with Diabetic Nephropathy develop into renal
failure. In this stage, patients have continuous proteinuria. The filtration
function declines progressively, which leads to renal failure. Serum creatinine
and blood urea nitrogen increase which are accompanied by high blood pressure,
hypoproteinemia and edema. In addition, patients in this stage can also have
poor appetite, vomiting, nausea, and so on, all of which are actually symptoms
So from the above mentioned, we can get a conclusion that we should find out
Diabetic Nephropathy as soon as possible so that effective measures can be taken
to prevent it from deteriorating.