Main Reasons of Diabetic Nephropathy
Diabetic Nephropathy occurs among patients with diabetes over ten years. Proteinuria is the obvious early symptom of Diabetic Nephropathy. According to clinical practices of dozens of years, the main reasons of Diabetic Nephropathy are as following:
1. High Blood Sugar
Poor control of blood sugar speed up the process of Diabetic Nephropathy. The increase of blood sugar and glycosylation wastes arouses proliferation of mesangial cells, more extracellular matrix, expansion of mesangial membrane, incrassation of basilar membrane.
2. Abnormal blood flowing condition of kidneys
a) IV Collagen of glomeruli makes basilar membrane thicker leading to diffusive and segmental mesangial lesion. As a result, it causes Glomerular Sclerosis.
b) When there are too much blood sugar, high perfusion, high filtration and crossing high pressure of blood capillary enlarge the mesangial cells and arouse the foot fusion of epithelial cells, leading to the drop of epithelial cells from basilar membrane.
c) Due to high blood pressure, more proteins leak out of blood and accumulate in mesangial area and renal basilar membrane, leading to matrix proliferation and diffusive Glomerular Sclerosis.
3. Hypertension(High Blood Pressure and Kidney Disease)
Hypertension is not relevant with Diabetic Nephropathy directly. But primary Hypertension and high blood pressure during the treatment can speed up the worsening process of Diabetic Nephropathy, so as to more protein leaking out of blood.
4. Inherited Factors
Most patients with Diabetes don’t suffer from Chronic Kidney Disease, but some patients who control blood sugar well stand Diabetic Nephropathy. Besides that, the incidence of Diabetic Nephropathy shows the familial aggregation. Meanwhile, the incidence in different races are various. All these show that the occurrence of Diabetic Nephropathy is related to inherited factors.
Due to insufficiency of Diabetes absolutely or relatively caused by different reasons, the metabolism of sugar, protein and fat is obstructed, leading to the main symptom of Chronic Blood Sugar. Diabetes can cause damage to the whole kidneys. Patients with Diabetic Nephropathy find continuous Proteinuria, they should take timely proper treatment to avoid the end stage of Chronic Kidney Disease—Uremia.
