The first stage of Diabetic Nephropathy is characterized by increased GFR(glomerular filtration rate) and increased kidney size. Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. If glomerular filtration rate increases in this stage, it proved that some glomeruli are damaged due to insufficiency of blood and oxygen, etc, so the remained renal glomeruli will do more work to replace what the having damaged ones did before. Luckily, in this stage, patients’ condition is reversible. After Diabetic Nephropathy apply insulin, they can recover.
In the second stage, the albumin in urine is normal. But the structure of some renal glomeruli begins to change. UAE will increase after patients with Diabetic Nephropathy take exercise. They can also recover after having a rest.
In the third stage, the discharge rate of albumin is 20--200μg/ min. In addition, the blood pressure can also increase, and some renal glomeruli become deserted. Kidney disease symptoms begin to appear, so we can also call this stage early stage of Diabetic Nephropathy.
The fourth stage is called clinical Diabetic Nephropathy or dominant Diabetic Nephropathy. The characteristic of this stage is a large amount of proteinuria(Proteinuria and Kidney Disease), edema and high blood pressure. Edema is relatively serious in this stage. Patients with Diabetic Nephropathy have bad reaction to diuretic.
In the last stage, patients with Diabetic Nephropathy will develop into the advanced stage of kidney disease, which can also be called uremia stage. In this stage, the filtration function declines, which leads to renal failure. In addition, patients can also have secondary nerve lesion and heart disease. These above mentioned complications are often the real reason why patients with Diabetic Nephropathy lost their life.
The above mentioned are about manifestations of the different stages of Diabetic Nephropathy. Generally, people should have physical examination once a year. Once diagnosed with Diabetic Nephropathy, patients should take effective measure as soon as possible. As for the treatment, we recommend the combination of Chinese medicine and western medicine, which is called Micro-Chinese Medicine Osmotherapy and Immunotherapy. In general, Micro-Chinese Medicine Osmotherapy help create a clean inner environment and then Immunotherapy can repair the damaged islet beta cells and damaged intrinsic cells in kidney.
