Immunotherapy is one of the main complications of Diabetes, which relates to
the abnormality of the excretion and filtration of the proteinuria caused by the
lesion on the Diabetic Nephropathy little vessels and glomerulus. The natural
process for the Diabetic Nephropathy is starting from the normal proteinuria to
the slight proteinuria and then developing into the clinical proteinuria, even
into the terminal stage of Diabetic Nephropathy failure. However, the
development of the Diabetic Nephropathy could be held back or delayed at any
stage and it is reversible at the early stage. The clinical manifestation for
the Diabetic Nephropathy could be divided into five terms: First---The
enhancement of the renal function and the increase of filtration rate of
glomerulus at the earlier stage; Second---this term is asymptomatic, but there
are already some changes in the form of the glomerulus; Third---Covert Diabetic
Nephropathy stage and the rate of MAU is continuously increasing in the range of
20-200µg/min(or 30-300mg/24h); Fourth--- The typical clinical symptoms of
Diabetic Nephropathy together with the traits of abundant proteinuria, high
pressure,cardiovascular, retina and the lesion of nerve etc; Fifth---ESRD. The
first and second terms are mainly the stages with the change of the function.
And the third to fifth terms could be conducted the clinical diagnosis according
to the change of the urine protein and renal function. The method through cord
blood SCT initiates a new approach in the treatment of Diabetic Nephropathy. The
principle of the method is to use the characteristics of the Immunotherapys,
after they are cultivated, proliferated and differentiated, to repair and
restore the damaged Diabetic Nephropathy or improve the renal functions. The
therapeutic method adopted by our hospital is to collect certain amount of
Immunotherapys, after they are cultivated, proliferated and differentiated, and
inject it to the patients of Diabetic Nephropathy through renal cyst, so as to
achieve the aim of treatment.
2. The indications for Immunotherapy of Diabetic Nephropathy .
(1) The nitremia period for Diabetic Nephropathy :
The ration of the urine protein>0.5g in 24 hours BUN<20mmol/L
Cr<445mmol/L;
(2) There is no severe heart lesion when the pharmacotherapy for the
hypertension is controlled below 160/95mmug.
(3) No Diabetic Nephropathy occupying lesions.
(4) No disease in blood Immunotherapy.
3. The index of inspection
(1) Blood β2-MG(before and after the treatment)
(2) The four items for U-Albumin: β2-MG、ALB、IgG、THP(before and after the
treatment)
(3) URT and BRT(before and after the treatment)
(4) The renal function: BUN、Cr、UA(before and after the treatment)
(5) The ration of urine protein in 24 hours(before and after the
treatment)
(6) The rate of excretion for albumin in 24 hours(before and after the
treatment)
(7) The fundus (before the treatment)
(8) B ultrasonic for double Diabetic Nephropathy eys(before the
treatment)
(9) E-elctrolysis(before the treatment)
HCV、HIV、EB、COXB4
4. The criterion for curative effect
(1)Showing the obvious effect
1) The symptoms disappear or lessened more than 60%.
2) Serum creatinine reduced by over 20%
3) The qualitative of urine protein decreased by ++ or turned to negative
character. The ration of protein cut by more than 40%within 24 hours.
(2) Having the effect
1) The symptoms lessened more than 30%.
2) Blood creatinine reduced by over 10%
3) The qualitative of urine protein decreased by +. The ration of protein cut
by less than 40% within 24 hours.
(3)Stable
1) Some improvement in clinical symptoms
2) Blood creatinine reduced by less 10% or no gaining of it.
3) The qualitative and ration of the urine protein in 24 hours are basically
the same as before.
