The first one is the ischemia and anoxia of renal nephrones.
In diseased conditions, people’s blood circulation is abnormal and the common
case is that the speed of blood flow is slowed down. Accompanied with slower
blood flow, there will be more sedimentation of detrimental substances on the
vascular walls. This influences the absorption of effective materials of renal
cells. And this ischemia and anoxia situation finally causes damage to
kidney.
The second one is the inflammatory reactions of renal nephrones
Infiltration of inflammatory factors generally caused by bacterium, virus and
the situation of ischemia and anoxia will lead to inflammatory reactions of
renal nephrones. And this will also result in damages to renal cells or even
give rise to the break down and apoptosis of renal cells.
The third one is coagulopathy
The break down and apoptosis of renal epithelial cells and mesangial cells
will lead to hemorrhage, which activates soterocyte and results in excessive
coagulation. And undue coagulation makes it more difficult to infiltrate blood,
and this extra burden will surely cause damages to renal nephrones.
The fourth one is high blood viscosity
Excessive absorption of fat and sugar will lead to high blood viscosity. This
is because of the high viscosity of these two substances. And high blood
viscosity will surely cause difficulty to blood filtration and subsequently
result in damages to renal nephrones.
The fifth one is the undue proliferation of extracellular matrix
Researches have proven that once renal nephrones die away, extracellular
matrix will occupy the space through proliferation. After that, these extra
matrixes will squeeze healthy renal nephrones and cause damages to them.
In conclusion，the process of renal being damaged is also one of kidney
functional declination . At last there will be only partial renal nephrones can
work and the disease aggravates into Uremia.
